Activation of Retinal Angiogenesis in Hyperglycemic pdx1−/− Zebrafish Mutants
نویسندگان
چکیده
منابع مشابه
Zebrafish retinal mutants
We have initiated a genetic analysis of the zebrafish visual system to identify novel molecules involved in vertebrate retinal function. Zebrafish are highly visual; they have four types of cones as well as rod photoreceptors, making it possible to study both rod and cone-mediated visual responses. To identify visual mutants, optokinetic responses of mutagenized larvae are measured in a three-g...
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PURPOSE To characterize morphologic and physiological alterations in the retina of three laminin mutant zebrafish, bashful (bal, lama1), grumpy (gup, lamb1), and sleepy (sly, lamc1), which were identified in forward genetic screens and were found to be impaired in visual functions. METHODS Mutant larvae were observed for defects in visual behavior by testing their optokinetic response (OKR). ...
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Neovascular age-related macular degeneration is a leading cause of irreversible vision loss in the Western world. Cytokine-targeted therapies (such as anti-vascular endothelial growth factor) are effective in treating pathologic ocular angiogenesis, but have not led to a durable effect and often require indefinite treatment. Here, we show that Nutlin-3, a small molecule antagonist of the E3 ubi...
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The process of angiogenesis is essential for tumor progression and metastasis. New pathways have been identified to play a critical role in promoting and regulating blood vessel formation both in embryogenesis and in pathophysiological conditions. These pathways provide potential molecular targets for anti-angiogenic therapies to treat cancer and other vascular diseases. The critical cellular t...
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Epiboly, the enveloping of the yolk cell by the blastoderm, is the first zebrafish morphogenetic movement. We isolated four mutations that affect epiboly: half baked, avalanche, lawine and weg. Homozygous mutant embryos arrest the vegetal progress of the deep cells of the blastoderm; only the yolk syncytial layer of the yolk cell and the enveloping layer of the blastoderm reach the vegetal pole...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2020
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db19-0873